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KMID : 1143220180610050615
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Obstetrics & Gynecology Science
2018 Volume.61 No. 5 p.615 ~ p.620
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The effect of tamoxifen therapy on the endometrium and ovarian cyst formation in patients with breast cancer
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Lee Seul
Kim Yun-Hwa
Kim Seung-Chul
Joo Jong-Kil
Seo Dong-Suh
Kim Ki-Hyung
Lee Kyu-Sup
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Abstract
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Objective: To evaluate the effect of tamoxifen on female reproductive organs in women with breast cancer.
Methods: We retrospectively reviewed the medical records of 309 women with breast cancer who were currently receiving tamoxifen and undergoing regular gynecological examination.
Results: We evaluated 92 pre- and 217 postmenopausal women. The prevalence of endometrial thickening was 12% in the pre- and 10.6% in the postmenopausal group. An endometrial biopsy was performed in 43 women and confirmed endometrial cancer in 1, endometrial polyps in 14, and endometrial hyperplasia in 4 women. Transvaginal ultrasonography showed 25 cases of newly developed ovarian cysts. Most ovarian cysts had disappeared during follow-up.
Conclusion: Tamoxifen use in women with breast cancer causes few complications and is considered safe for female reproductive organs in case of regular gynecological examination.
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KEYWORD
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Tamoxifen, Endometrium, Breast neoplasms, Ovary
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